FEIBA [Anti-Inhibitor Coagulant Complex] Glossary

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Proteins that are part of your immune system and help protect your body. Different antibodies attack different things that are foreign to your body.2

Blood Clot

A thickened mass in the blood formed by platelets.24

Bypassing Agents

Treatments given to patients with inhibitors to help their blood clot by getting around the normal way that clots form, which is blocked by the inhibitors.9

Clotting Cascade

A series of steps that occur in the formation of a clot, involving the clotting proteins and other substances.25

Clotting Factor

Substances in your blood that help it clot. The different factors are named with Roman numerals and include factors I, II, V, VII, VIII, IX, X, XI, XII, and XIII. An "a" after the Roman numeral means that it's an activated type of that factor (factor VIIIa, IXa, etc).25


Events or incidents.


See "Clotting Factor."

Family History

If one or more of your family members have had a certain condition or disease, you are said to have a "family history" of that condition or disease. Also, when your healthcare professional asks you questions about what conditions your family members have had, he or she is getting your "family history."


A condition that stops your blood from clotting normally due to a lack of one of the clotting factors.25

Hemophilia A

The type of hemophilia caused by a lack of factor VIII.25

Hemophilia B

The type of hemophilia caused by a lack of factor IX.25


The administration of clotting factor concentrates.25


Agents that block a biological or chemical process. In hemophilia, they are antibodies that attack and inactivate the factors in your treatment and stop them from helping your blood to clot.25


The protein-rich portion of the blood, which carries the red blood cells, white blood cells, and platelets.25


Routine infusion to help prevent bleeds.25


As-needed infusion to treat bleeds when they happen.19

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FEIBA [Anti-Inhibitor Coagulant Complex] Indications

What is FEIBA used for?
FEIBA (Anti-Inhibitor Coagulant Complex) is used for people with Hemophilia A or B with Inhibitors to control and prevent bleeding episodes, before surgery, or routinely to prevent or reduce the number of bleeding episodes. It is NOT used to treat bleeding conditions without inhibitors to Factor VIII or Factor IX.

Detailed Important Risk Information

When should I not take FEIBA?
You should not take FEIBA if you have had hypersensitivity or an allergic reaction to FEIBA or any of its components, including factors of the kinin generating system, if you have a condition called Disseminated Intravascular Coagulation, which is small blood clots in various organs throughout the body, or currently have blood clots or are having a heart attack. Make sure to talk to your healthcare provider about your medical history.

What Warnings should I know about FEIBA?
FEIBA can cause blood clots, including clots in the lungs, heart attack, or stroke, particularly after high doses of FEIBA or in people with a high risk of blood clots. Patients that have a risk of developing blood clots should discuss the risks and benefits of FEIBA with their healthcare provider since FEIBA may cause blood clots. FEIBA can cause hypersensitivity or allergic reactions and infusions site reactions, and these reactions can be serious. Because FEIBA is made from human plasma, it may carry the risk of transmitting infectious agents, for example, viruses, including Creutzfeldt-Jakob disease (CJD) agent, and the variant CJD agent. Although steps have been taken to minimize the risk of virus transmission, there is still a potential risk of virus transmission.

What should I tell my healthcare provider?
Make sure to discuss all health conditions and medications with your healthcare provider. If you are pregnant or are planning to become pregnant, or are a nursing mother, make sure to talk with your healthcare provider for advice on using FEIBA.

What are the side effects of FEIBA?
The most frequent side effects of FEIBA are: low red blood cell count, diarrhea, joint pain, hepatitis B surface antibody positivity, nausea, and vomiting. The most serious side effects of FEIBA include: hypersensitivity reactions, including anaphylaxis, stroke, blood clots in the lungs, and blood clots in the veins. Always immediately talk with your healthcare provider if you think you are experiencing a side effect.

What other medications might interact with FEIBA?
The use of other clotting agents with FEIBA is not recommended, for example, tranexamic acid and aminocaproic acid. Be sure to talk with your healthcare provider and pharmacist about all medications and supplements you are taking.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

The risk information provided here is not comprehensive. To learn more, talk about FEIBA with your healthcare provider or pharmacist. The FDA-approved product labeling can be found at http://www.feiba.com/us/forms/feiba_pi.pdf or by calling 1-800-423-2090 and selecting option 5.