Inhibitors are tricky. We can help.
Timmy, Actual FEIBA Patient
FEIBA is made to help you manage inhibitors to factors VIII and IX to help you prevent bleeds. It's also made with your safety in mind.1
We have a history of helping people with inhibitors. FEIBA has been approved for on-demand treatment for over 40 years.14
FEIBA is approved in more than 60 countries worldwide.14
FEIBA has been indicated for prophylaxis in more than 40 countries since 2013.14
Developed with HIGH standards.
You need to know that what you put into your body is as safe as possible. The purification process for FEIBA was created with your safety in mind.1
FEIBA is made with care at every step, from the plasma sourced and screened to the purification and testing.15
Made with care every step of the way.15
All plasma donors pass rigorous screenings for qualification
Each plasma donation is tested for human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV)
Plasma from qualified donors is held for 60 days
Next up: viral serologic testing for HBV surface antigen, HCV antigen and antibody, HIV-1 and HIV-2 antibodies, and HIV p24 antigen is performed on all plasma donations
And more: nucleic acid amplification tests (NAT) for HIV, HCV, HBV, hepatitis A virus (HAV), and parvovirus B19 (PV B19)
FEIBA [Anti-Inhibitor Coagulant Complex] Purification Process15
As with all plasma-derived products, the risk of transmission of infectious agents cannot be totally eliminated. As of November 10, 2014 (from self-reported databases), there have been no confirmed reports of transmission of hepatitis A, B, or C or human immunodeficiency virus (HIV) associated with the use of FEIBA since the introduction of vapor heat treatment (ongoing surveillance indicates this remains valid).16
Selected Important Risk Information for FEIBA [Anti-Inhibitor Coagulant Complex]
WARNING: EVENTS INVOLVING CLOTS THAT BLOCK BLOOD VESSELS
- Blood clots that block blood vessels and their effects have been reported during post-marketing surveillance following infusion of FEIBA, particularly following the administration of high doses and/or in patients with a risk of forming blood clots.
- If you experience any of these side effects, call your doctor right away.
At first sign or symptom of a sudden blood vessel clot or blocked blood vessel (e.g., chest pain or pressure, shortness of breath, altered consciousness, vision, or speech, limb or abdomen swelling and/or pain), stop FEIBA administration promptly and seek emergency medical treatment.
Allergic-type hypersensitivity reactions, including severe, sometimes fatal allergic reactions that can involve the whole body, can occur following the infusion of FEIBA. If you experience any of these signs or symptoms, stop FEIBA administration immediately and seek emergency medical treatment.
Because FEIBA is made from human plasma it may carry a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.
Here's how FEIBA works.
Bypassing agents—like FEIBA—are important treatments for people with inhibitors. Because factor VIII or IX treatment will no longer be effective, FEIBA gets around the need for these factors and helps your blood form clots to stop bleeding.1,17,18
FEIBA acts at multiple sites in the clotting cascade.18
In vitro analysis
FEIBA contains several different clotting factors—factors II, IX, and X, mainly non-activated; and factor VII, mainly in the activated form.1
FEIBA acts at multiple sites in the clotting cascade and helps restore thrombin generation in people who have hemophilia with inhibitors. Thrombin helps with the formation of the fibrin clot, which helps stop bleeding.1,18
Bypassing inhibitors: the play-by-play.
- For hemophilia A and B patients with inhibitors, clotting doesn't occur naturally during bleeding due to missing factor VIII or factor IX.3
- As shown above, FEIBA bypasses (or "gets around") the need for these factors and helps your blood form clots to stop bleeding.1,18
- FEIBA provides several different clotting factors—factors II, IX and X, mainly non-activated; and factor VII, mainly in the activated form—and works at different sites in the clotting system.1,18
- This restores thrombin generation and helps with the formation of the fibrin clot, which stops bleeding.1,18
Find out if feiba is right for you.
You may be eligible for 15 free trial doses of FEIBA.
All you need to do is complete some information with help from your healthcare provider.
- Download the form and fill it out with your healthcare provider.
- If eligible, you will receive your free trial doses of FEIBA.
Want to learn more? Check out our How It Helps page.