Tools & Resources / Glossary



Proteins that are part of your immune system and help protect your body. Different antibodies attack different things that are foreign to your body.2

Blood Clot

A thickened mass in the blood formed by platelets.24

Bypassing Agents

Treatments given to patients with inhibitors to help their blood clot by getting around the normal way that clots form, which is blocked by the inhibitors.9

Clotting Cascade

A series of steps that occur in the formation of a clot, involving the clotting proteins and other substances.25

Clotting Factor

Substances in your blood that help it clot. The different factors are named with Roman numerals and include factors I, II, V, VII, VIII, IX, X, XI, XII, and XIII. An "a" after the Roman numeral means that it's an activated type of that factor (factor VIIIa, IXa, etc).25


Events or incidents.


See "Clotting Factor."

Family History

If one or more of your family members have had a certain condition or disease, you are said to have a "family history" of that condition or disease. Also, when your healthcare professional asks you questions about what conditions your family members have had, he or she is getting your "family history."


A condition that stops your blood from clotting normally due to a lack of one of the clotting factors.25

Hemophilia A

The type of hemophilia caused by a lack of factor VIII.25

Hemophilia B

The type of hemophilia caused by a lack of factor IX.25


The administration of clotting factor concentrates.25


Agents that block a biological or chemical process. In hemophilia, they are antibodies that attack and inactivate the factors in your treatment and stop them from helping your blood to clot.25


The protein-rich portion of the blood, which carries the red blood cells, white blood cells, and platelets.25


Routine infusion to help prevent bleeds.25


As-needed infusion to treat bleeds when they happen.19

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FEIBA [Anti-Inhibitor Coagulant Complex]
Indications and Detailed Important Risk Information for Patients

INDICATIONS FOR FEIBA [Anti-Inhibitor Coagulant Complex]

FEIBA is an Anti-Inhibitor Coagulant Complex indicated for use in hemophilia A and B patients with inhibitors for:

  • Control and prevention of bleeding episodes
  • Use around the time of surgery
  • Routine prophylaxis to prevent or reduce the frequency of bleeding episodes.

FEIBA is not indicated for the treatment of bleeding episodes resulting from coagulation factor deficiencies in the absence of inhibitors to coagulation factor VIII or coagulant factor IX.

  • Blood clots that block blood vessels and their effects have been reported during post-marketing surveillance following infusion of FEIBA, particularly following administration of high doses and/or in patients with a risk of forming blood clots.
  • If you experience any of these side effects, call your doctor right away.

You should not use FEIBA if:

  • You had a previous severe allergic reaction to the product (reactions causing discomforts that are damaging and life threatening)
  • You have signs of development of small blood vessel clots throughout the body
  • You have sudden blood vessel clots or blocked blood vessels, (e.g., heart attack or stroke)

Events involving blood clots blocking blood vessels can occur with FEIBA, particularly after receiving high doses and/or in patients with risk factors for clotting.

Infusion of FEIBA should not exceed a dose of 100 units per kg body weight every 6 hours and daily doses of 200 units per kg of body weight. Maximum injection or infusion rate must not exceed 2 units per kg of body weight per minute.

At first sign or symptom of a sudden blood vessel clot or blocked blood vessel (e.g., chest pain or pressure, shortness of breath, altered consciousness, vision, or speech, limb or abdomen swelling and/or pain), stop FEIBA administration promptly and seek emergency medical treatment.

Allergic-type hypersensitivity reactions, including severe, sometimes fatal allergic reactions that can involve the whole body, can occur following the infusion of FEIBA. Call your doctor or get emergency treatment right away if you get a rash, hives or welts, experience itching, tightness of the throat, vomiting, abdominal pain, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.

Because FEIBA is made from human plasma it may carry a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

The most frequent side effects observed during the prophylaxis trial were anemia, diarrhea, bleeding into a joint, signs of hepatitis B surface antibodies, nausea, and vomiting.

The serious side effects seen with FEIBA are allergic reactions and clotting events involving blockage of blood vessels, which include stroke, blockage of the main blood vessel to the lung, and deep vein blood clots.

Call your doctor right away about any side effects that bother you during or after you stop taking FEIBA.

Please see FEIBA full Prescribing Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.