PROOF Study Quality-of-Life results

Improvements in physical HRQoL1,2

Reduced annual bleed rates (ABRs) led to improvements in physical HRQoL among haemophilia patients with inhibitors.1,2 Patients on FEIBA prophylaxis showed a trend toward improvements in HRQoL versus those who received on-demand treatment, but this trend was not statistically significant.1,2*†

  • After 12 months of follow-up, patients on prophylaxis reported a mean improvement of 0.08 on the EQ-5D index score and 15.7 on the EQ-5D VAS, both larger than the established minimal important difference (MID) for these measures (0.07 and 7, respectively).1,2

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Trend toward improved function and overall HRQoL1,2

The EQ-5D health profile showed the following trends in percentage of prophylaxis patients reporting improved function when compared with the on-demand patients: mobility (17% vs. 6%), self-care (25% vs. 6%), and usual activities (25% vs. 12%), anxiety/depression (31% vs. 33%), and pain/comfort (19% vs. 17%).1,2†

  • With regard to Haem-A-QoL, prophylaxis patients reported improvement in physical health-related quality of life (HRQoL) (21.9) and overall HRQoL (9.5), which was larger than the estimated MID thresholds (11.4 and 7.7, respectively)(ns).1,2†

Notations

ns=not significant
* The relatively small sample size limited the ability to detect significant differences in improvements between on-demand and prophylaxis groups.
† Not significant
‡ 12 months
§ When controlling for age and time.

References

  1. 1. Antunes SV, Tangada S, Stasyshyn O, et al. Randomized comparison of prophylaxis and on-demand regimens with FEIBA NF in the treatment of haemophilia A and B with inhibitors [published online ahead of print August 1, 2013]. Haemophilia. 2014;20(1):65-72. DOI:10.1111/hae.12246.
  2. 2. Stasyshyn O, Antunes SV, Mamanov V, et al. Health-related quality of life in hemophilia patients with inhibitors receiving prophylaxis with anti-inhibitor coagulant complex (AICC): results from AICC Prophylaxis Study. Abstract presented at: XXIV Congress of the International Society on Thrombosis and Haemostasis; June 29-July 4, 2013; Amsterdam, the Netherlands.

The results are in

In the Pro-FEIBA study (n=26), FEIBA prophylaxis showed a significant reduction in the frequency of bleeding events in severe haemophilia A patients with FVIII inhibitors Read more

Publications

Visit Haemophilia to read the PROOF Study and access to more articles related to managing haemophilia patients with inhibitors. Read more

Sustained activity

FEIBA offers a long dosing interval. Read more

Demonstrated efficacy in prophylaxis

Learn how FEIBA prophylaxis can reduce bleed frequency and preserve joints. Read more

Dosing FEIBA

Learn how to dose FEIBA. Read more