Learn about the indications for FEIBA.
The PROOF Study demonstrated that FEIBA prophylaxis resulted in a significant reduction in annual bleed rates (ABRs) for joint bleeds and target joint bleeds. FEIBA prophylaxis also showed a trend towards reducing the development of new target joints (ns).1* The authors also suggest that prophylaxis could prevent repeated joint bleeding—a promising hypothesis for patients who start primary prophylaxis at an early age.1
Access haemophilia treatment guidelines and protocols outlined by the World Federation of Hemophilia. Full article
View recommendations from the World Federation of Hemophilia on practical approaches to treating patients with Factor VIII inhibitors. Full article
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Important Safety Information
FEIBA must not be used in the following situations if therapeutic alternatives to FEIBA are available:
Thrombotic and thromboembolic events, including disseminated intravascular coagulation (DIC), venous thrombosis, pulmonary embolism, myocardial infarction, and stroke have occurred in the course of treatment with FEIBA, particularly after administration of doses above the maximum daily dose and/or prolonged application or in patients with other risk factors for thromboembolic events.
As with any intravenously administered plasma product, allergic type hypersensitivity reactions may occur; patients should be informed of the early signs of hypersensitivity reactions. When medicines prepared from human blood or plasma are administered, the possibility of passing on infection cannot be totally excluded. This also applies to any unknown or emerging viruses or other types of infections.
Administration of FEIBA to patients with inhibitors may result in an initial anamnestic rise in inhibitor levels. Upon continued administration of FEIBA, inhibitors may decrease over time. Clinical and published data suggest that the efficacy of FEIBA is not reduced.
* ns = not significant.
Defined as ≥ 4 haemarthroses in a single joint during a 6-month study period.